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This is accomplished by insulin binding to its receptors on the vascular endothelial cells

These alterations usually revert to normal over a few weeks to months

Alterations in SSTRs signal transduction might be the cause of typical octreotide-resistance observed in acromegalic patients bearing germline mutations in aryl hydrocarbon receptor interacting protein (AIP) gene (58) or expressing low levels of AIP, even in the absence of mutations

Most cases are temporary and resolve within 3 to 6 months once weight stabilizes

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