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however, organ damage during MTX treatment reduces its therapeutic effectiveness (Reference Shinde, Venkatesh and Kumar32)
Additionally, its ability to reduce stress by stabilizing the hypothalamic-pituitary-adrenal (HPA) axis and lowering cortisol levels may further alleviate depressive symptoms (3)
Based on these findings, recommendations for the requirements on test bench components are formulated in this paper, in order to contribute to new certification guidelines
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