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Description

Science 363 , 10931097 (2019)

425,447,448,449 OT release from oxytocinergic neuron axon terminals in the VTA drives the excitability of dopaminergic neurons in the NAc, and eventual activation of the PVNVTA circuit enhances social behaviour

This is the highest among all current medications

Subsequent trials, including SUSTAIN-6, Harmony Outcomes, and AMPLITUDE-O, reported similar MACE reductions but without a mortality benefit [15,16,17]