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Parkinsonism & Related Disorders 2003

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Physiological Reviews, 99 (1), 665706

Acknowledgements We thank all the researchers who have spent their time and effort in trying to understand the complexity of this issue, and we extend our apologies if we could not accommodate a particular work in this review because of space constraints

Here we will discuss two pathologic conditions were GLP-1 has been associated with hypoglycemia, in congenital hyperinsulinism due to inactivating mutations in the K ATP channels and in postprandial hypoglycemia after gastrointestinal surgery, where the delivery of nutrients to the small intestine is altered resulting in both hyperglycemia and an exaggerated secretion of GLP-1