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Reasons to increase your dose include plateau in weight loss after an initial response, inadequate appetite suppression despite consistent use, or sufficient tolerance to previous doses without significant nausea or constipation

In clinical trials, duloxetine has demonstrated effectiveness in reducing symptoms of depression, anxiety, fibromyalgia, neuropathic pain, and stress urinary incontinence

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Animal studies report biological activity after oral administration, especially in gastrointestinal models, which suggests potential local effectiveness