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The pyruvate dehydrogenase complex (PDHC), which serves as the critical enzymatic bridge between glycolysis and the tricarboxylic acid cycle, has been found to be markedly deficient in postmortem brain specimens from Alzheimers disease patients (Gibson et al., 1988)
Its antioxidant approach is also more layered
68 GholamiM.ZendedelA.Khanipour khayatZ.GhanadK.NazariA.PirhadiA
However, the concentrations of both allopurinol and oxypurinol achieved during in vivo pharmacotherapy seem to be too low for their antioxidant effect (if there is any) to be of therapeutic importance ( in vitro and/or in model animals (Pacher et al., 2006)
The resulting infection leads to inflammation and disfiguring surface breakouts
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