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Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)

Overall, prostate cancer is the third leading cause of cancer-related death among men, especially as they get older

Behne F., ZFP Sdwrttemberg Weissenau, Department of Epileptology

Burdo J, Dargusch R, Schubert D

7 biggest news story of 2025: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), in widespread use to treat diabetes and obesity, have also demonstrated off-label benefits for a multitude of conditions, including cardiovascular disease, hypertension, Parkinsons, Alzheimers and some addictive disorders