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1 However, recent randomised controlled trials (RCTs) have demonstrated the efficacy of some GLP-1 RAs for weight reduction in adults even without diabetes, leading to semaglutide and liraglutide approval as adjuncts to a calorie-restricted diet and exercise for weight management.2, 3, 4 Tirzepatide, a newer dual receptor agonist, has also been demonstrated to induce greater weight reductions, 5 and has recently been approved for patients without diabetes in some countries

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Signs of dehydration or acute kidney injury also warrant prompt attention

Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway

Best taken on empty stomach at least 10 minutes before meals