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This process is vital for cellular respiration, where cells convert fats into energy to maintain optimal energy production

Notably, limited data were available for people with BMI 40 kg m 2 , the elderly, adolescents and people with overweight (BMI 25 kg m 2 and 25 kg m 2 ), with a treatment duration of at least 48 weeks, which compared OMMs with the specific indication of obesity treatment with either placebo or other OMM

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The use of targeted nanocarriers solves the problems of both insufficient brain penetration of hydrophilic therapeutic molecules and high treatment doses inducing side-effects at the periphery [21, 26]