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Its most effective when used as part of a comprehensive plan that includes a balanced, reduced-calorie diet and regular physical activity

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Still outstanding: TRIUMPH-5 (head-to-head vs tirzepatide) TRIUMPH-6 (weight maintenance) and the MASH / MASLD readouts TRIUMPH-Outcomes (cardiovascular and kidney outcomes) -- a multi-year, event-driven trial Lilly said it plans to submit a Biologics License Application (BLA) for retatrutide to the FDA in the first quarter of 2027 , based on the core TRIUMPH results and supporting filings for obesity, obstructive sleep apnea, and knee osteoarthritis

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This may improve adherence to the treatment regimen, as seen with other once-weekly GLP-1 receptor agonists such as semaglutide (Ozempic) and dulaglutide (Trulicity)