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Conclusion and Perspectives The understanding of brain Se transport has considerably improved, first of all, over the past two decades

Personal or family history of gout is the most significant predictor, as these individuals already have a predisposition to elevated uric acid levels or impaired uric acid handling

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If so, NET-directed diagnostics (e.g., circulating MPODNA or citrullinated histone H3) and targeted interventions (DNase, PAD4 inhibitors, anti-platelet strategies that disrupt plateletneutrophil conjugation) could represent novel approaches to mitigate CV risk in PCOSan avenue that urgently warrants prospective, mechanism-focused clinical investigation (see Fig