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van Eenige, R

In general, medications that enhance the effects of GLP-1 can cause gastrointestinal side effects including diarrhea, gas and bloating

The effects of acetyl-l-carnitine on the expression of these neurotrophins in pain conditions is still debated, but an anti-hyperalgesic effect could derive from a better harmonisation of their activity

This can make dose escalation smoother and more tolerable

Nutritional strategies should emphasize whole foods, adequate protein intake (0.81.0 g/kg body weight, adjusted for kidney function if needed), and mindful portion control rather than severe caloric restriction, which can further suppress metabolic rate