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However, their precise temporal sequence requires further investigation

In a randomized, placebo-controlled trial in 1,374 participants who had colonoscopic removal of at least one colorectal adenoma (the Selenium and Celecoxib trial), selenium supplementation (200 g/day with selenized yeast) for a median of 33 months had no effect on colorectal adenoma recurrence (88)

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After full-text screening and eligibility assessment based on inclusion criteria, 43 studies were included for final data extraction (Fig

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