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Eli Lilly announced Phase 3 ATTAIN-1 trial results for orforglipron, an oral GLP-1 receptor agonist, showing significant weight loss in adults with obesity or overweight without diabetes

The subcutaneous tissue surrounding the knee provides adequate proximity for peptide diffusion to ligaments, tendons, and the joint capsule

To further validate the potency of these two drug candidates, it is imperative to confirm the result via in vitro enzymatic studies and in vivo diseased animal model study

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Available both as an injection and an oral pill, semaglutide functions by emulating GLP-1, a natural hormone that reduces appetite and encourages significant, durable weight loss