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Lentigo maligna melanoma is closely associated with sun exposure
While eumelanin shows photoprotective capacity against ultraviolet (UV) [15], in contrast pheomelanin is weakly photoprotective and highly phototoxic, enhancing the UV-induced production of reactive oxygen species (ROS) and further damage of cells [16]
Cancer 74 , 255259 (1997)
Kensler, Thomas W