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Role of PTHrP and PTH-1 receptor in endochondral bone development

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In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)

However, an elevated first trimester A1C shows a low sensitivity (14.5%) but high specificity (97.5%) for predicting second-trimester GDM (251)