Ethics declarations Competing interests SK and DR are coinventors of a patent on the culture of anaerobic bacteria using antioxidants (1H53 316 CAS 9 FR)
The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance
GLP-1, glucagon-like peptide-1;AC, adenylate cyclaseTNF-, tumor necrosis factor-IL-1, interleukin-1 AMPK, AMP-activated protein kinaseAkt, protein kinase BPKA, protein kinase API3K, phosphoinositide 3-kinasemTORC1, mammalian target of rapamycin complex 14EBP1, Eukaryotic translation initiation factor 4 E-binding protein 1GSK3, glycogen synthase kinase 3MyoD, myogenic regulatorGLUT4, glucose transporter 4FOXO, fork head box protein OLC3, microtubule-associated protein light chain 3NF-KB, nuclear factor kappa light chain enhancer of activated B cellsMURF-1, Muscle Ring Finger Protein-1PGC-1, peroxisome proliferator-activated receptor gamma coactivator-1 SIRT1, deacetylase 1Sestrin2, stress inducible protein 2ULK1, Unc-51-like autophagy-activated kinase 1
Notably, ASCT2 is overexpressed in highly proliferative cancer cells to meet the increasing demand for Gln, making it a promising cancer target
doi: 10.3389/fcell.2020.583850 Received 15 July 2020 Accepted 31 August 2020 Published 18 September 2020 Volume 8 - 2020 Edited by Vadivel Ganapathy, Texas Tech University Health Sciences Center, United States Reviewed by David Thwaites, Newcastle University, United Kingdom
