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Decreased vitamin B12 absorption due to altered gut microbiota Potential for megaloblastic anemia in prolonged use Increased risk of neuropathy and other neurological complications Dose and Duration Considerations The risk of B12 deficiency with metformin depends on the dose and how long you take it

freezing denatures the protein [9]

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Side Effects & Precautions

While some yeast spreads, soy milks and soy-based meat-replacement products are fortified with B12, it is recommended that vegetarians and vegans take a supplement in order to maintain adequate levels