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Mechanisms of vagus nerve stimulation for the therapy of neurodevelopmental disorders: an emphasis on microglia and neuroinflammation
A 2026 review in the American Journal of Sports Medicine emphasizes that despite popularity, "significant research regarding the safety and efficacy of these therapeutic methods is required before definitive recommendations can be made to patients." Only a single human case series exists for BPC-157 (for knee pain), with significant methodological flaws and no controls
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