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Some may respond better to GLP-1 alone, while others benefit from a combination therapy

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Based on our recent work showing that diet-induced weight loss improves stroke recovery in association with decreased neuroinflammation, astrocyte reactivity and reduced type 2 diabetes-induced atrophy of parvalbumin-positive interneurons, without reduction of stroke volume [13], we speculate that these cellular mechanisms are also involved after semaglutide/BI8271-induced weight loss