As weight loss restores GH levels (9294), this indicates that the blunted GH secretion is an effect rather than a cause of obesity
At the cellular level, glutathione functions as a cofactor for antioxidant enzymes like glutathione peroxidase and glutathione-S-transferase, which neutralize reactive oxygen species and support phase-II detoxification pathways
In addition, microglia and astrocytes support OL lineage responses during myelination and remyelination, in part via secretion of growth factors that can act on OL receptors 51,138,184,185
To our knowledge, this is among the first trials to comprehensively assess aescin in this context and to compare its efficacy directly with rutin while investigating adjunctive interaction with standard antithyroid medication
Ethics declarations Competing interests In the past 3 years, J.W.M