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The resulting peptideresin (25 mol scale) was treated with a solution of 92.5% trifluoroacetic acid (TFA), 2.5% water, 2.5% triisopropylsilane and 2.5% ethanedithiol, to yield the free linear N -ClAc-peptide

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This dose level showed significantly enhanced efficacy in clinical trials compared to 1.0mg, with the STEP trials demonstrating a clear dose-response relationship for weight reduction