However, practically and procedurally, they are not direct substitutes in multi-draw protocols
Sometimes unexplained worsening of symptoms can be seen after having been administered several supplementations, even as long as weeks later
Conclusion Two thirds of an unselected group of ME/CFS patients treated for 3 months with vitamin B12 nasal drops had a favorable outcome in objective measures and subjective patient reported outcome, which were associated with a significant increase in serum vitamin B12 levels
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