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The drugs enhanced participants motivation, but increased the amount of time they spent solving a problem by 50%, with scientists saying they spent almost as much time on the easiest instances under MPH as on the hardest instances under a placebo, without any corresponding improvement in performance. While under the prescriptive stimulants, scientists reported peoples efforts increased while the quality of their efforts decreased, meaning they did more, but their decisions were not as calculated as they were random

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Caused by peripheral vasodilation via nitric oxide signaling

Eur Heart J 2011