Summary and outlook In recent years, substantial clinical and basic research has advanced our understanding of heat stress-induced liver injury, yet its complex pathogenesischaracterized by interconnected mechanisms including hyperthermia-induced direct hepatocyte damage, oxidative stress, inflammatory cascades, and diverse programmed cell death modes (apoptosis, necroptosis, pyroptosis, ferroptosis)remains incompletely elucidated
activation of Nrf2, the cellular protective pathway
doi: 10.1016/S0169-328X(03)00162-1 68 HwangD
Managing GERD, maintaining healthy weight, avoiding smoking/alcohol, and eating anti-inflammatory foods significantly reduce progression risk through prevention-focused naturopathic care
The cytotoxic activity of cultured cells was determined in a standard 4-h 51 Cr release assay against K562