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Subsequently, the medium was replaced with fresh medium containing 0.1% BSA and indicated concentrations of metformin, and cells were incubated for 2 h at 37C

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Non-traditional mechanisms of AR action Processing of AR target genes and transcripts These renewed insights support the ever-increasing complexity and context-dependency that is being recognized in the control of AR over ARE-driven gene expression, which it executes in large part via interactions with its elaborate and diverse protein interactome

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