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For research prospects, current anti-aging studies of the product are mainly conducted at the cellular and animal levels

498 Proteomic analysis of astrocytes from astrocyte-specific knock-out GDI1 animals 499 revealed a significant change in the expression of genes responsible for glucose homoeostasis

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The linkage of NAD + metabolism to the internal clocks is firstly evidenced by that the NAD(P) + /NAD(P)H ratio modulates the DNA-binding activity of the core oscillators, such as CLOCK: BMAL1 and NPAS2: BMAL1 heterodimers

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