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Multi-omics analyses of serum metabolome, gut microbiome and brain function reveal dysregulated microbiota-gut-brain axis in bipolar depression

( g ) Normalized BHB levels in whole pCO and dCO from WT and HMGCS2 iOE mice

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1 For patients who do not achieve their target A1C with metformin, the Diabetes Canada 2018 guidelines recommend selecting add-on therapy based on individual patient characteristics