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Economic Impact and Access Challenges The financial burden of GLP-1 medications remains substantial, with average prescription costs exceeding $1,500 ^26

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Approval typically takes 7 to 14 days but can be expedited with thorough, accurate records

Several mechanisms including glucotoxicity, lipotoxicity, altered secretion of adipokines/cytokines, hepatokines (mainly higher circulating fetuin-A levels), stimulation of multiple inflammatory pathways, reduced bile-acid synthesis, endoplasmic reticulum stress, increased oxidative stress, mitochondrial dysfunction and alterations in gut microbiota/gut-derived endotoxins, in a complex interplay with genetic predisposition, drive the evolution of inflammation, hepatocellular injury and fibrosis [2426]