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Abnormal expression has been associated with a wide variety of pathologies, including hepatitis,6 HIV,7 and a wide variety of cancers, including skin,8 kidney,9 bowel,10 and breast.11 Glutathione reductase (GR)- catalyzes reduction of glutathione disulfide is by requires NADPH producing two glutathione molecules as an end product

There are two different forms of glutathione: reduced glutathione (GSH, or L-glutathione), which is the active form oxidized glutathione (GSSG), the inactive form

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Cancer 106(5):1017-25, 2006