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Commonly suggested biomedical hypotheses to explain PAIS (such as in long COVID/PASC, ME/CFS) are chronic stimulation of the immune system by a persistent infection or persistent unviable pathogen structures

A study by Hu et al

CJC-1295 maintains the GHRH signal for longer, and pairing it with Ipamorelin (a selective secretagogue acting on the ghrelin receptor) produces a larger, sustained, dual-pathway GH pulse with a clean side effect profile

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10.1056/NEJMoa043160 38 RamaekersV