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Melasma often appears on areas of the skin frequently exposed to sunlight, like the forehead, cheeks, and upper lip, indicating that hormonal fluctuations and UV exposure can work together to exacerbate pigmentation

Baluchnejadmojarad, R

Both preclinical and clinical studies show that circadian disruption aggravates BBB injury, characterized by reduced expression of tight junction proteins (ZO-1, occludin, claudin-5), heightened neuroinflammation (TNF-, IL-1), MMP-9/2mediated extracellular matrix degradation, and HPA axis dysregulation

In addition to developing therapeutic agents that target the reprogramming of ammonium metabolism in prostate cancer, it is essential to identify reliable indicators for evaluating treatment efficacy, such as sensitivity-related gene signatures and metabolomic profiling (277)

All analyses were controlled by HP ChemStation software