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Appetite control may improve fueling consistency, while stable blood sugar levels help avoid energy crashes

Moreover, continued bone metabolism impairment over time in the aftermath of weight loss has been reported in postmenopausal women despite maintaining a stable weight, suggesting a progressive or even delayed effect [7]

[DOI] [PubMed] [Google Scholar] 80.Scirica B.M., Braunwald E., Raz I., Cavender M.A., Morrow D.A., Jarolim P., Udell J.A., Mosenzon O., Im K., Umez-Eronini A.A., et al

doi: 10.1371/journal.pone.0142081 87 RaiNUpadhyayADGoyalVet al

In this study, the central mechanism underlying TAM lipid metabolic reprogramming relies on NP-mediated targeted siCB-2 delivery to TAMs, which silences CB-2 expression, disrupts the 2-AG signaling cascade, and redirects TAM polarization toward the pro-inflammatory M1 phenotype, ultimately restoring anti-tumor immune responses