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The mechanism is well-characterized at the biochemical level: GSH inhibits tyrosinase, the rate-limiting enzyme in melanin biosynthesis, by binding to its copper-containing active site

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A major unsolved mystery is concerning how PUFAs peroxidation cause ferroptosis [69]

The lessons learned from astrocyte-targeted strategies provide a natural transition to examining microglia, whose dual role as immune defenders and potential drivers of pathology makes them equally compelling therapeutic targets (Figure 5)