These mitochondria-containing erythrocytes produce interferongenic mtDNA that serve as immunogenic DNA in SLE, inducing IFN- production through the activation of the cGASSTING pathway in macrophages (132)
Review Articles Marasco, M, Kumar, D, Garcia Borrego, S, Seale, T, Maddalena, G, Mezzadra, R, Belanger, K, Cole, S, Perez, B, Luan, W, Mukherjee, R, Aricescu, I, Markov, V, Zhu, Y, Arena, S, Bardelli, A, De Stanchina, E, Lowe, SW, Burkhart, RA, Zimmerman, JW, Yaeger, R, Kopetz, S , Rosen, N, Misale, S
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Furthermore, the gut microbiome is associated with changes in brain structure and function in SZ patients, as evidenced by neuroimaging studies linking microbial -diversity to alterations in gray matter volume and regional homogeneity (75)
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