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In rodents and humans, peripherally administered GLP-1R agonists transiently stimulate the HPA axis and increase circulating levels of corticosterone, aldosterone, and ACTH [[815], [816], [817]]

73 People with non-proliferative diabetic retinopathy requiring acute therapy, proliferative diabetic retinopathy and macular edema have not been studied in the SURPASS program and for these patients tirzepatide should be used with caution and appropriate monitoring

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