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Preclinical studies using native GLP-1 or GLP-1RA have provided convincing evidence of its cardioprotective benefits, while clinical trials have shown positive effects on hypertension and dyslipidemia in patients with T2DM [3]

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nevertheless, despite all PDE5i provided well-established efficacy results in placebo-controlled RCTs, direct comparison studies among the various PDE5i are scarce, and a clear consensus concerning the most efficient PDE5i is lacking, also due to heterogeneity of methods used to address penile erectile function [57]

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Multiple clinical trials confirm this with consistent results