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They are present in the 2025 List of Prohibited Substances and Methods of World AntiDoping Agency in the subsection S2.2.4 Growth hormonereleasing factors [15]

Patients Affected by Drug Shortages The FDA's drug shortage database lists ongoing shortages across multiple therapeutic categories [8]

It also acts as an intermediate in the pathway for valine, threonine, methionine, thymine, isoleucine, cholesterol and odd-chain fatty acids

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