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These exerkines act through autocrine, paracrine, or endocrine mechanisms to mediate inter-organ communication, playing essential roles in regulating nervous system function, attenuating neuroinflammation, and promoting neural repair ( 2+ , lactate dehydrogenase (LDH), MDA, and lipid ROS, inhibited neuronal ferroptosis and lipid peroxidation, thereby ameliorating oxygen-glucose deprivation and reoxygenation (OGD/R)-induced neuronal injury
doi: 10.1056/NEJMoa2107519 197 AbdallaMADeshmukhHAtkinSSathyapalanT
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Carnitine deficiency reduced energy synthesis by impairing fatty acid degradation [17], and was reported to be associated with diabetes and its complications [18]
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