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Common Side Effects Peripheral edema (swelling of ankles or feet) most frequent Flushing (warmth or redness of face) Headache Dizziness or lightheadedness Fatigue Less Common / Rare Side Effects Palpitations or rapid heartbeat Nausea or abdominal discomfort Hypotension (low blood pressure) Gingival hyperplasia (gum overgrowth) rare Rash or itching Important Notes Usually well-tolerated Swelling in the legs is dose-related Can be used safely in most adults with other comorbidities Monitor blood pressure regularly

doi:10.1111/acer.13234 [PubMed] 38

Nettleton et al, 2020)

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It can block the release of cytochrome c by binding to mitochondrial voltage-dependent anion channels (VDAC), inhibit FLS apoptosis, and promote its abnormal proliferation (82, 83)