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When stressed, neurones limit their activity to preserve energy

2018;38:BSR20171440

Since this cascade is confined to the intracellular mevalonate-CoQ10 metabolic pathway and does not intersect with NPC1L1-mediated dietary cholesterol absorption in intestinal epithelium, and since relevant in vitro experiments were conducted under standard serum-containing culture conditions without evidence of extracellular lipid deprivation, clinically used doses of simvastatin do not attenuate its ferroptosis-promoting effects by interfering with intestinal lipid absorption

[7] This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism

Brehm A, Pfeiler G, Pacini G, Vierhapper H, Roden M