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In studies using the Duchenne muscular dystrophy mouse model ( mdx ), both the genetic crossing of mdx mice with Mstn / mice and the administration of the MSTN-neutralizing antibody mRK35 led to similar outcomes, specifically increased muscle mass and improved grip strength.[24,25] However, another mouse study reported that Mstn / mice, despite having increased muscle mass, did not exhibit a corresponding increase in muscle strength.[26] Although there are conflicting results regarding the ability of MSTN inhibition to improve muscle functions, such as muscle strength, most studies consistently show that inhibition of MSTN results in a significant increase in muscle mass

This process, known as delayed gastric emptying, means that food stays in your stomach longer, contributing to a prolonged feeling of fullness

Rosenstock J, Wysham C, Fras JP et al (2021) Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

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November 2008