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Description

In mouse and cell models of amyotrophic lateral sclerosis (ALS), IGF1 also strongly protects mitochondria from apoptosis and upregulates mitophagy, as evidenced by a decrease in the p62 level and an increase in the LC3-II level (Wen et al., 2019)

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Enhancing ferroptosis in these resistant cells could potentially reduce tissue remodeling and inflammation

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Little is known about the long-term physiologic effects of these medications, and increased use among plastic surgery patients warrants further study relevant to the field

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