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Ferroptosis, characterized by lipid peroxide accumulation and GSH depletion, is modulated by NO through direct enzyme inhibition, iron metabolism regulation, and potentiation of immunogenic cell death (ICD)

Acknowledgements We thank Steven Flavell, Cassi Estrem, Yun Zhang, Chun-Liang Pan, Luciano Marraffini, Dennis Kim, and members of the Bargmann lab for their comments on the manuscript

Regular B12 supplementation can support these vital systems and help prevent complications like anemia and neurological symptoms in those at risk

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