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The peak amplitude of a change in fluorescence induced by GLP-1, GLP-1MK-801 or NMDA was calculated by taking an average of ten datapoints from the baseline ( F 0 ) and subtracting this from an average of ten data points from the peak fluorescence ( F : average amplitude peak average amplitude baseline ), which was normalized by dividing by F 0

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Therefore, therapeutic agents targeting GSTO1 and IL-1 might be capable of treating or ameliorating neurodegenerative diseases

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Off-Target Activity Later animal research acknowledged the need to optimise the compound in relation to clearance and off-target activity against monoamine oxidase A