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The proposed mechanism involves the matrix metalloproteinase activity that breaks down old collagen faster than new collagen replaces it

Characterization of hydroxyl radical modified GAD65: a potential autoantigen in type 1 diabetes

These studies show that chronic usage of APAP at recommended therapeutic levels probably does mild liver damage and may be associated with a reduction in GSH levels that compromise antioxidant defense capacity

Following this observation, several in vitro and in vivo studies demonstrated that the expression of necroptosis-related proteins (RIPK1, RIPK3, and MLKL) was simultaneously induced following CP administration (Gao et al., 2016

Biederer T, Sudhof Thomas C, Sara Y, Mozhayeva M, Atasoy D, Liu X, et al