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The latest data also shows that most people stop taking GLP-1s within 12 months and experience significant side effects throughout treatment

He J-G, Zhou H-Y, Wang F, Chen J-G (2023) Dysfunction of glutamatergic synaptic transmission in Depression: focus on AMPA receptor trafficking

The STEP 1 trial, published in the New England Journal of Medicine, showed that this sustained caloric reduction led to an average weight loss of 14.9% of body weight over 68 weeks