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References Maquart, F

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Animal studies in diet-induced obesity models show tesofensine treatment produces selective reduction in adiposity with improvements in insulin sensitivity, reductions in plasma lipids, and decreased accumulation of abdominal and subcutaneous fat mass

These disruptions may contribute to (although not solely responsible for) various pathological conditions such as depression, anxiety, cardiovascular disease, and metabolic disorders such as type 2 diabetes

Other common additives utilised by the food industry include microbial transglutaminase (mTG) and, although useful for modifying the functionality of dietary protein, has been found to increase intestinal permeability and suppress pathways involved in protection against enteric pathogens (Santos and Torn 2009