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As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)

Prep Biochem Biotechnol 51(2):127136 Agrawal S, Barrow CJ, Adholeya A, Deshmukh SK (2022) Unveiling the dermatological potential of marine fungal species components: antioxidant and inhibitory capacities over tyrosinase

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