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If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution

Is your refrigerator maintaining 2-8C consistently

Rotate injection sites to prevent irritation or lipodystrophy at any single location

The duration of therapy for intranasal treatment is tested, commonly used, and deemed safe for at least 18 months

Pickart and Margolinas 2018 review in Int J Mol Sci catalogs its regenerative and protective actions matrix remodeling, antioxidant and anti-inflammatory gene modulation, and wound-repair signaling but this is a review of largely preclinical and cell-based work (PMC6073405)